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Year : 2018  |  Volume : 1  |  Issue : 1  |  Page : 17-24

Challenges in glioblastoma biology and implications in personalized therapy

National Centre for Cell Science, RNA Biology and Cancer Laboratory, S.P. Pune University Campus, Pune, Maharashtra, India

Correspondence Address:
Dr. Anjali Shiras
National Centre for Cell Science, RNA Biology and Cancer Laboratory, S.P. Pune University Campus, Pune - 411 007, Maharashtra
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/IJNO.IJNO_7_18

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Glioblastoma is one of the most dreaded tumors of the central nervous system. The tumors show poor prognosis with patients showing a median survival of only 12–15 months despite all the treatment regimens. Recent studies have contributed a lot to our understanding of the pathogenesis of this disease and have suggested the presence of glioma stem cell (GSC) population as drivers of tumor growth. The GSCs are also considered responsible for tumor recurrence leading to treatment failure. It is thus increasingly becoming important to understand the biology of this tumor and effectively classify these tumors based on genetic mutations. Advancement in diagnosis to uncover the stages of tumor development and customize treatment modalities would increase chances for better responsiveness to various treatments and help us witness positive outcomes. These altogether could help in improving the survival of patients and their quality of life. An urgent need to find better ways of diagnosis could be achieved by combining our knowledge of basic science with advanced technologies. This review summarizes the past and present status of glioma biology, their classification and pathogenesis. It highlights the current pitfalls in clinical treatment and recent advances in diagnostics which could have clinical implications in near future.

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