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Year : 2020  |  Volume : 3  |  Issue : 1  |  Page : 38-41

Collision tumor: Metastatic renal cell carcinoma to cerebellar hemangioblastoma in Von Hippel-Lindau disease

Department of Neurosurgery, Smt NHL Medical College and SVP Hospital, Ahmedabad, Gujarat, India

Correspondence Address:
Dr. Nirmal L Desai
Department of Neurosurgery, Smt NHL Medical College and SVP Hospital, Ahmedabad - 380 007, Gujarat
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/IJNO.IJNO_3_20

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A tumor-to-tumor metastasis, also known as collision tumor, is a rare metastatic process in which primary malignant tumor metastasizes to another tumor. Meningioma has been implicated as the most common intracranial neoplasm to harbor metastasis, with donor tumor is the most common lung or breast tumor. Here, we describe the case of metastasis of renal cell carcinoma (RCC) to capillary hemangioblastoma (HAB) of the cerebellum in a patient of Von Hipple-Landau (VHL) disease. Patients with hereditary cancer syndromes may be at increased risk for the development of tumor-to-tumor metastasis. We review the literature about RCC to HAB metastasis and described the pathological and immunohistochemical findings of both the tumor to distinguish the two and to do clinical diagnosis of VHL syndrome.

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